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SARMs Learn more about SARMs Benefits Selective Androgen Receptor Modulators
(SARMs) as Function Promoting Therapies
Purpose of
review
The last
decade has witnessed unprecedented discovery effort to develop selective
androgen receptor modulators (SARMs) that improve physical function and bone
health without adversely affecting the prostate and cardiovascular outcomes.
This review describes the historical evolution, the rationale for SARM
development, and the mechanisms of testosterone action and SARM selectivity.
While
steroidal SARMs have been around since the 1940s, a number of nonsteroidal
SARMs that do not serve as substrates for CYP19 aromatase or 5α-reductase, act
as full agonists in muscle and bone and as partial agonists in prostate are in
development. The differing interactions of steroidal and nonsteroidal compounds
with AR contribute to their unique pharmacologic actions. Ligand binding
induces specific conformational changes in the ligand binding domain, which
could modulate surface topology and protein-protein interactions between AR and
coregulators, resulting in tissue-specific gene regulation. Preclinical studies
have demonstrated the ability of SARMs to increase muscle and bone mass in
preclinical rodent models with varying degree of prostate sparing. Phase I
trials of SARMs in humans have reported modest increments in fat-free mass.
SARMs hold
promise as a new class of function promoting anabolic therapies for a number of
clinical indications, including functional limitations associated with aging
and chronic disease, frailty, cancer cachexia, and osteoporosis.
Where to Buy SARMsIf you’re just skimming this article and want a high quality source to purchase SARMs from, we recommend Platinum Muscle Nutrition .
Every batch of their SARMs are 3rd party
verified, so you know that they’re at least 99% pure, verified by an
independent laboratory.
When ordering SARMs online, you need to be very
careful—only get them from a reputable vendor, as many vendors sell fake SARMs
laced with dangerous prohormones, or even worse.
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